Dr. Sadhana Mendhurwar

56Dr. Sadhana Mendhurwar, Professor of Physiology, D. Y. Patil Medical College, Hospital & Research Centre and Ambassador India of European Lifestyle Medicine Organization (ELMO) Delivered a faculty Note at Geneva, Switzerland

The first European Lifestyle Medicine Congress was held in Geneva, Switzerland on November 10th – 11th, 2018. The intent was to bring together the most prestigious European and International professionalsacross nearly 35 countries, with clinic expertise and scientific recognition to facilitate the spread and exchange of evidence based knowledge, skills and attitudes between experts, researchers, clinicians and students. Dr. Sadhana Mendhurwar, Professor of Physiology, D. Y. Patil Medical College, Hospital & Research Centre and Ambassador India of European Lifestyle Medicine Organization (ELMO)delivered the faculty note about Patho-physiology of Lifestyle Disorders.

The talk analyzed medical-practitioners’ reports about increased-incidence of oncological-patients with diabetes-mellitus. Dr. Sadhana Mendhurwar focused on research indicating strong-links between these lifestyle-related disorders with multi-organ involvement, possibly due-to underlying common-factors like obesity, inflammation, glutamine-metabolism, oncogenes/tumor-suppressor-genes, hyperinsulinemia and hyperglycemia. While disturbance to glucose/metabolic-homeostasis causes diabetic-nephropathy, diabetic-retinopathy, diabetic-neuropathy, atherosclerosis,cardiovascular diseases, metabolic-syndrome; recent-research links diabetes to higher-mortality in cancer-patients. Animal-research-models linking hyperinsulinemia to metastasis through accelerated tumor-progression by activation of insulin/insulin-like growth-factor receptors (INSR/IGF1R), were covered. Studies considering protein-kinase AKT/PKB as key-mediator of insulin-effects on aggressive tumor-cells, through direct-activation of NF-κB protein-complex in-response-to lifestyle-inflicted inflammations, were discussed. Mutant-response of P53 (“guardian-of-the-genome”), primary-culprit in ~50% cancers, expressed-through protein-folding-mechanisms affected-by cellular-stresses/HPA-axis was analyzed. This session discussed state-of-the-art research highlighting pathophysiological-links between Immunology, Nutrition-Physiology, Meta-inflammation, Stress and Lifestyle-imbalances.

The informative and research-oriented session was highly appreciated by the European and International medical fraternity.